Meijer, R.J.H. (2010) Een in vivo studie naar biodegradeerbaar polyurethaanschuim gemodificeerd met 5,5 % polyethyleenglycol (PEG)als lokaal hemostaticum na gebitsextracties. thesis, Dentistry.
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Abstract
Introduction. Nowadays, a considerable high number of patients uses oral anticoagulants for therapy. When a planned surgical procedure like tooth extraction is needed, these patients are often required to stop the anticoagulant therapy prior to the treatment. Otherwise, haemostatic disorders may cause excessive bleeding after treatment. With the use of a completely synthetic, local haemostatic agent, there is no longer a requirement to cease the oral anticoagulants and risk a thrombo-embolisation. In this in vivo study the goal was to evaluate the suitability and feasibility of a new developed polyurethane foam as a haemostatic agent. Materials and Methods. The research design is a single blinded and split-mouth study in 60 patients. The patients included were over 18 years old, healthy and underwent two dental extractions (molar) in one session. The patients were at random allocated into two groups of 30 patients each. In group 1, a polyurethane foam was inserted in one extraction socket and in the other extraction socket, a gelatin foam (Spongostan ®).In group 2, a polyurethane foam was inserted in one extraction socket and in the other extraction socket, a collagen foam (Hemocollagene ®).All the applied samples were removed after 2 minutes and extracted in a 1,5 ml micro tube with 250f.!l 0,2M EDT A liquid. These micro tubes were centrifuged and the supernatant was stored at a -20°C. Measurement of the degree of coagulation in the different samples was done by the use of ELISA thrombin-antithrombin-test and ELISA fibrinogen-test on these extracts. Results. Thrombin was induced and fibrinogen was depleted by all three hemostatic agents, without significant difference between the samples. Conclusion. All three local hemostatics have the same capabilities in being a haemostatic agent. This implies that the choice of material can be dependent on other properties, such as ease of handling, safety and costs.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Bos, Prof . dr. R.R.M. and Broekema, drs. F.l. and Kaakchirurgie, UMCG |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:49 |
| Last Modified: | 25 Jun 2020 10:49 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/996 |
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