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Faculty of Medical Sciences

Discriminating Chronic Heart Failure in Chronic Obstructive Pulmonary Disease.

Nieuwenhuis, M. (Maartje) (2009) Discriminating Chronic Heart Failure in Chronic Obstructive Pulmonary Disease. thesis, Human Movement Sciences.

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Abstract

Chronic Heart Failure (CHF) is not diagnosed in about 20o/o of the patients with Chronic Obstructive Pulmonary Disease (COPD). The symptoms linked to CHF have an overlap with the symptoms of COPD. The aim of this exploratory study is to examine diagnostic criteria to discriminate patients with CHF in a group of patients with COPD. Diagnostic criteria used in this study are: NT-proBNP, ~Vo2/b.Load, the 0 2 pulse and V02. Three groups will be included in this study; patients with COPD, patients with CHF and patients with COPD&CHF. All patients are recruited out of the out patients treatment. The b.Vo2/b.Load, the 0 2 pulse and V02 will be measured in an cycle ergo meter test and the levels of serum NT-proBNP values will be measured in the blood. In total 67 patients were included in this study; 25 patients with only COPD, 20 patients with COPD and diagnosed CHF and 22 patients with CHF. Levels of NT-proBNP differed significantly between the three groups. A correlation of r=0.599 was found between NTproBNP and LVEF. The 02 in rest of patients with COPD is significant lower than patients with COPD&CHF (p=0.043) and CHF (p=0.008). The values of the ~V02/~Ioad are widely deviated in COPD and in COPD&CHF. Patients with COPD&CHF who do take beta blockers have the slope of CHF and patients without beta blockers have the slope of COPD. Conclusion of this study is that NT-proBNP in combination with the 02 in rest, is a good measurement to control for CHF in patients with COPD.

Item Type: Thesis (Thesis)
Supervisor name: Wempe, Dr. J.B. and Greet, Dr. M.H.G. de
Faculty: Medical Sciences
Date Deposited: 25 Jun 2020 10:48
Last Modified: 25 Jun 2020 10:48
URI: https://umcg.studenttheses.ub.rug.nl/id/eprint/908

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