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Faculty of Medical Sciences

De invloed van comorbiditeit op aseptische en septische loslating van een totale knieprothese.

Doornbos, S. (Stefan) (2013) De invloed van comorbiditeit op aseptische en septische loslating van een totale knieprothese. thesis, Medicine.

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Abstract

Background: Several international studies examined the effects of comorbidity on loosening of a Total Knee Prosthesis (TKP). However the influence of comorbid conditions on loosening of a TKP in the Dutch population is not clear. Aim of this study was to examine the prevalence of comorbid conditions and their influence on aseptic and septic loosening of a TKP in a Dutch population. Methods: Retrospective cohort study, which was executed at University Medical Center Groningen. Patients with aseptic or septic loosening of a TKP between January 2007 and December 2012 were included. Comorbid conditions were selected based on the Charlson comorbidity index and the 30 most common chronic diseases, as defined by the Dutch National Institute for Public Health and the Environment (RIVM). Odds ratios for comorbid conditions were calculated using univariate and multiple logistic regression analyses. Results: Aseptic loosening occured in 50 patients and 13 had septic loosening of a TKP. Hypertension, cardiovascular disease, diabetes mellitus, overweight and obesitas were more prevalent in patients suffering from loosening of a TKP. Diabetes mellitus (OR 0,1; p = 0,040) was the only predictor for aseptic loosening. Predictors for septic loosening were pre-operative anemia (OR 6,2; p = 0,025) and overweight (OR 9,9; p = 0,071). Conclusion: Diabetes mellitus was associated with an increased risk of aseptic loosening. Pre-operative anemia and overweigh were predictive for septic loosening of a TKP. Results of this study are in line with earlier results of international studies, new associations were not found.

Item Type: Thesis (Thesis)
Supervisor name: Stevens, M. and Nieboer, K.M.
Faculty: Medical Sciences
Date Deposited: 25 Jun 2020 10:47
Last Modified: 25 Jun 2020 10:47
URI: https://umcg.studenttheses.ub.rug.nl/id/eprint/856

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