Tumor-specific diagnostic values of the diagnostics for lung cancer.

Mandigers, L. (Lotte) (2014) Tumor-specific diagnostic values of the diagnostics for lung cancer. thesis, Medicine.

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Abstract

Background: Early and accurate diagnostics is crucial for a patient with suspected lung cancer, since delay in the diagnostic process may result in an even poorer prognosis. The aim of this study is to give an overview of tumor-specific diagnostic values of several examinations including chest radiograph, CT, PET-CT, bronchoscopy, TBNA, EBUS-TBNA, EUS-FNA and thoracentesis in patients with suspected or proven lung cancer. Methods: In this retrospective descriptive study, data were collected of patients who had a diagnostic procedure for suspected lung cancer at the Catharina Hospital in Eindhoven, the Netherlands, between January 2011 and August 2013 if their health complaint was registered with the diagnosis treatment combination (DBC) ‘tumors’. This study included patients with suspected or proven lung cancer, recurrent disease, mediastinal or pulmonary metastases or pleuritis carcinomatosa. We evaluated the results of the tests and calculated the diagnostic values using the standard definitions. Results: We included 785 patients with suspected or proven lung cancer. The sensitivities of the imaging modalities and bronchoscopy were influenced by the size, the histologic type and the location of the tumor. Sensitivities of TBNA, EBUS-TBNA, EUS-FNA were influenced by the result of mediastinal staging with PET-CT. Chest radiograph, brushing, washing, biopsy and TBNA had a low NPV, negative results should therefore be confirmed with further tests. Approximately half of the mediastinoscopies could be avoided using endosonographic procedures. Conclusions: A standard work-up for patients with suspected lung cancer is available. However, for each individual patient the most appropriate tests should be chosen. This choice should not solely be based on the characteristics of the test itself, but the characteristics of the tumor should also be taken into account, including the size, the location and the histologic type of the tumor and the result of mediastinal staging with PET-CT.

Item Type:	Thesis (Thesis)
Supervisor name:	Wijnands, W.J.A. and Deventer Hospital and Borne, B.E.E.M. van den and Catharina Hospital Eindhoven
Faculty:	Medical Sciences
Date Deposited:	25 Jun 2020 10:47
Last Modified:	25 Jun 2020 10:47
URI:	https://umcg.studenttheses.ub.rug.nl/id/eprint/846

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