Manen, I.L. van (2015) De invloed van cannabis- en alcohol gebruik op het beloop van psychische stoornissen. thesis, Medicine.
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Abstract
INTRODUCTION The use of cannabis and alcohol is strongly increased among patients with a psychotic disorder. Cannabis use increases the risk of developing a psychosis. Alcohol use among patients with a psychotic disorder is associated with problems in multiple life domains. Studies show inconsistent results about the effects of cannabis and alcohol use on the course of psychotic symptoms and social functioning. METHODS In this retrospective study, the predictive values of cannabis and alcohol use on the course of psychotic disorders were investigated. Patients who joined both the Psychosis Recent Onset GRoningen Survey (PROGR-S) database and the Pharmacotherapy Monitoring and Outcome Survey (ROM-Phamous) were included. The PROGR-S database contains data of patients with a first psychotic episode or recently developed psychosis that has not been diagnosed previously. The ROM-Phamous database contains data of annual follow-ups of these patients. All patients had at least one follow-up. Logistic regression analyses were used to assess which factors are associated with cannabis and alcohol use at baseline. Multilevel regression analyses were used to assess the effect of cannabis and alcohol use on psychotic symptoms and social functioning. Psychotic symptoms were measured with the Positive and Negative Symptoms Scale (PANSS). Psychosocial functioning was measured with the Health of the Nation Outcome Scale (HoNOS), the Manchester Short Assesment of Quality of Life (MANSA) and the Global Assessment of Functioning Scale (GAF). RESULTS 157 Patients were included. There was no significant relation between cannabis and alcohol use and psychotic symptoms and social functioning. Patients with a first psychotic episode and who used cannabis were younger and had higher PANSS total scores than patients with a first psychotic episode who did not use cannabis. Patients with a first psychotic episode and who used alcohol had a higher IQ and more positive symptoms than patients with a first psychotic episode who did not use alcohol. CONCLUSION Cannabis use does not seem to predict the course of psychotic disorders. Alcohol use seems to worsen social functioning, although it improves global psychopathology. However, no concrete conclusions can be made because of the limitations of this study.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Facultair begeleider : and Veling, Dr. W.A. and Tweede begeleider : and Liemburg, Dr. E. and Locatie : Universitair Centrum Psychiatrie, Afdeling Psychos |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:46 |
| Last Modified: | 25 Jun 2020 10:46 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/727 |
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