Nugteren, M. (Marjan) (2015) Staging Bipolar-I-Disorder. thesis, Medicine.
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Abstract
INTRODUCTION Bipolar-I-disorder is a recurrent and potentially progressive chronic illness, with a heterogeneous course. Staging has proven to be effective in several medical fields but is not as yet applied in psychiatry, although researchers have proposed staging models in recent years. The aim of the present study was to examine whether a staging model may be applied on retrospective data in bipolar disorder. METHODS In this pilot study, 120 patients with bipolar-I-disorder were included, using data from the Bipolar Genetics (BiG) study. We used data on illness-history, current symptoms and everyday functioning. In order to aid the staging process, an adapted staging model was formulated and a flowchart developed, resulting in an assignment to stage 0 to 4. Stage 2 and 3 were further subdivided into a, b and c. Independent illness variables were associated with the assigned stage. RESULTS 108/120 patients could be assigned to a stage. Patients assigned to stage 2(a,b,c) were significantly older at the time of diagnosis and had shorter duration of illness. Stage 2(a,b,c) patients had a higher GAF score than patients assigned to stages 3(a,b,c), or 4. Patients who suffered their first manic episode more than 15 years ago were all assigned to stages 3b, 3c or 4. CONCLUSIONS This pilot-study has proven that it is feasible to apply a staging model to bipolar-I-disorder. The progressive nature of the disorder is reflected by the findings of this study.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Faculty supervisor: and Ruhé, H. G. MD PhD |
| Supervisor name: | Location supervisors: and Klumpers U. M. H. MD PhD and Kupka R.W. MD PhD and GGZ inGeest, partner of VU University Medical and Center Amsterdam, Department of Psychiatry. |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:45 |
| Last Modified: | 25 Jun 2020 10:45 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/606 |
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