Zwager, M. (Mieke) (2017) Een verstoring in de balans van tumor-geassocieerde macrofagen leidt tot ongunstige tumorkenmerken in HER2-positief mammacarcinoom. thesis, Medicine.
Full text available on request.Abstract
Breast cancer is the most prevalent invasive malignancy in women worldwide. Human Epidermal growth factor Receptor 2 (HER2) is amplified in 15-20% of breast cancers. HER2 positive breast cancer is highly aggressive and associated with poor prognosis, rapid spreading and has high recurrence rates and poor survival. Over the last few years treatment has improved, but prognosis remains unsure. It is thought that the tumour microenvironment and its tumour-associated macrophages are of great importance in cancer development and progression. It is suggested that under physiological conditions a balance exists between antitumour M1 macrophages and pro-tumour M2 macrophages. In this research the relation between disturbance in this balance and clinicopathological characteristics of HER2-positive breast cancer was investigated. Digital image analysis was used to count the amount of M1 macrophages and M2 macrophages and to calculate the M2:M1 ratio in 106 primary HER2- positive breast cancers. We found a higher mean count of M2 macrophages compared to M1 macrophages in tumours. Therefore a high mean M2:M1 ratio was found. An increase in the number of M2 macrophages and a higher M2:M1 ratio were significantly correlated with high tumour grade. Low macrophage count was significantly related with higher expression of androgen- and estrogen receptors. Significant correlations with overall survival and relapse free survival were not found. These results suggest that there indeed is a disbalance between subgroups of tumour-associated macrophages in HER2 positive breast carcinomas. This disbalance may play a role in the development of poor tumour characteristics.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Facultair begeleider and Vegt, Dr. B. van der and Pathologie en Medische Biologie and Universitair Medisch Centrum Groningen |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:44 |
| Last Modified: | 25 Jun 2020 10:44 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/592 |
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