Heijn, E. (2018) De invloed van IgG en/of IgA MAR antistoffen in het sperma op mannelijke subfertiliteit. thesis, Medicine.
Full text available on request.Abstract
Background: There are several causes that could lead to subfertility. In 30% percent, the cause remains unclear. Possibly, the presence of antisperm antibodies (ASA) could be a cause of male subfertility, although there is still no consensus. Therefore, the aim of this study was to examine the influence of ASA on subfertility. Methods: Sperm parameters of all men who visited the outpatient clinic of the department of gynaecology during 2003-2017 were collected. Couples with ASA positive men (≥50%) were included in the study. The following parameters were collected: Operations and diseases which could lead to positive ASA, medication and diseases which could possibly lead to reduction of fertility, pregnancy rates, the way of conception, the kind of fertility treatment, and pregnancy outcome. Results: 175 subfertile couples with ASA positive male were included. Positive ASA prevalence was 7,5% in the subfertile population, whereby in 33,9% a possible cause of positive ASA was identified. The presence of positive ASA did have a significant negative effect on the amount of oligoasthenoteratozoospermia (OAT) and teratozoospermia (p=<0,001 and p=<0,005). Although, the presence of positive ASA did not seem to have a negative effect on reproductive pregnancy rates. 49,7% of the couples with men with positive ASA became pregnant without fertility treatment. 24,2% of the couples experienced a miscarriage. Conclusions: The presence of positive ASA remained unexplained in the majority of males. Our study showed the presence of positive ASA should not play a part in the decision-making of starting a fertility treatment. It is justified to wait for 6-12 months until starting a fertility treatment, if ASA positive men did not have an OAT and no other cause of subfertility was observed. The presence of ASA might negatively effect the presence of miscarriages.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Facultair begeleider: and Linden, dr. P.J.Q. van der |
| Supervisor name: | Plaatselijk begeleider: and Linden, dr. P.J.Q. van der and Locatie: Deventer Ziekenhuis and Afdeling: Gynaecologie |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:44 |
| Last Modified: | 25 Jun 2020 10:44 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/586 |
Actions (login required)
 |
View Item |