Hiemstra, I.T. (Ieteke) (2012) Speekselcortisolrespons na een gestandaardiseerde rentest (shuttle-run) bij prepuberale kinderen met astma. thesis, Medicine.
Full text available on request.Abstract
Background: Children with asthma using inhaled corticosteroids (ICS) have a significant lower basal salivary cortisol level compared to healthy children. The relevance of this finding during illness or physical activity is unclear. In adults, short-term use of ICS results in a reduced cortisol response after exercise. Objective: Primary, comparison of salivary cortisol response after exercise in prepubertal children with asthma to healthy children. Secondary, investigation of the relation between salivary cortisol response and morning salivary cortisol level. Methods: Twenty healthy prepubertal children and 19 children with asthma using ICS (6-12 year) performed on two separate occasions a 20-meter shuttle-run test. Salivary cortisol levels were determined before, immediately after exercise and 15 minutes after exercise. At the same time, forced expiratory volume in the first second (FEV1) was determined in children with asthma. Morning salivary cortisol levels were determined from saliva samples collected at home. Results: Immediately after the shuttle-run test, salivary cortisol levels decreased significantly in both study groups. Fifteen minutes after the shuttle-run test, salivary cortisol levels increased significantly in healthy children (test 1: p < .001, test 2: p = .006), but not in children with asthma (n.s.). The duration of the shuttle-run test was significantly longer in healthy children (test 1: 5.3 min, test 2: 5.4 min) compared to children with asthma (test 1: 3.8 min, test 2: 4.0 min), p = .001 and p =.002 for respectively test 1 and test 2. No exercise-induced asthma was observed, except for one measurement after the second test (17% fall in FEV1). There was no correlation found between salivary cortisol response and morning salivary cortisol level. Conclusion: Children with asthma using ICS have a attenuated salivary cortisol response after exercise compared to healthy children. It remains unclear whether the reduced response may be explained by ICS use, the chronic inflammatory disease, the shorter duration of the exercise test or a combination of these factors. Further studies are needed to make this clear.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Facultair begeleider: and Kappelle, Dr. J.W. internist |
| Supervisor name: | Begeleider: and Kamps, Dr. A.W.A. kinderarts and Medisch Centrum Leeuwarden and Afdeling: and Kindergeneeskunde |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:39 |
| Last Modified: | 25 Jun 2020 10:39 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/56 |
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