Riemens, Annabel (2026) Mannelijk geslacht onafhankelijk geassocieerd met verhoogde mortaliteit bij type 2 diabetes mellitus: resultaten uit het DIALECT�cohor. thesis, Medicine.
Full text available on request.Abstract
Background: Sex differences in complications and mortality among patients with type 2 diabetes mellitus (T2DM) remain incompletely understood. This study investigated the association between sex and mortality, microvascular and macrovascular complications in the DIALECT-cohort. Methods: This prospective cohort study included 746 patients with T2DM (452 men and 294 women). Mortality during follow-up was the primary outcome. Secondary outcomes were microvascular complications (nephropathy, neuropathy, retinopathy) and macrovascular complications (myocardial infarction, stroke/transient ischemic attack, hospitalization for heart failure). Associations were assessed using Kaplan–Meier analyses and Cox proportional hazards regression. Results: During a median follow-up of 8.5 years for men and 9.5 years for women, 228 participants (30.6%) died. Men showed a significantly higher cumulative mortality risk than women (log-rank p=0.005). In multivariable analysis, male sex was independently associated with increased mortality risk (HR 1.56; 95% CI 1.16–2.11; p=0.004). Macrovascular complications were more prevalent in men (48.0% vs. 38.1%; p=0.008), but this association was insignificant after multivariable adjustment (HR 1.20; 95% CI 0.92–1.57; p=0.19). No significant association was observed between sex and microvascular complications (HR 1.11; 95% CI 0.94–1.32; p=0.21). The standardized mortality ratio was higher among women (3.65) than men (2.93). Conclusions: Men with T2DM experienced a higher mortality risk and greater prevalence of macrovascular complications than women. Male sex remained independently associated with 3 mortality, but not with microvascular or macrovascular complications. Nevertheless, women experienced a larger excess mortality relative to the general population. These findings underscore the need for sex-specific risk stratification in diabetes care
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Laverman, Prof. Dr. |
| Faculty: | Medical Sciences |
| Date Deposited: | 16 Oct 2026 08:44 |
| Last Modified: | 16 Oct 2026 08:44 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/3969 |
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