Krahwinkel, Anna-Katharina (2025) SGLT-2 inhibitors are effective in reducing HbA1c in patients with type 2 diabetes, but their effect is not enhanced by dietary intake: A retrospective observational cohort study. thesis, Medicine.
Full text available on request.Abstract
Background: Diabetes Mellitus type 2 (T2D) is a globally prevalent disease known for its serious complications. Its management consists of a combination of pharmacological and lifestyle interventions. As Sodium-glucose contransporter-2 (SGLT-2) inhibitors become increasingly important in the treatment of T2D, investigating factors that may enhance their effectiveness is essential to optimize T2D management. Objective: This study investigates whether the intake of carbohydrates, protein, fat and sodium influences the effectiveness of SGLT-2 inhibitors in achieving glycemic control, weight reduction, and if SGLT-2 inhibitors reduce albuminuria. Methods: This retrospective observational cohort study was conducted within the DIAbetes and LifEstyle Cohort Twente (DIALECT) and included 95 participants with T2D that used a SGLT-2 inhibitor. Data were collected through food questionnaires, physical examinations, and blood and urine samples. Spearman´s Rank correlation coefficient, one-way Analysis of Variance (ANOVA) and a Wilcoxon-signed rank test were used for the analysis. Results: The results showed a decrease in HbA1c of 7,4 mmol/mol after initiating treatment with a SGLT-2 inhibitor (mean=67,7, SD=12,28 at baseline vs mean=60,27, SD=11,07 post-treatment, p<0,001). No relationship was found between dietary intake and reduction in HbA1c. Also, a decrease in body weight of 1,9 kg was found (mean=99,3, SD=18,2 at baseline vs mean=97,4, SD=18,15 post-treatment, n=80, p<0,001). The intake of protein was moderately correlated with a greater reduction in body weight (rho=0,349, p=0,002, n=74). Conclusion: SGLT-2 inhibitors significantly reduced HbA1c in the study population and have a positive effect on weight loss. However, glycemic control was not affected by dietary intake.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Laverman, Prof. Dr. G.D. and Teunissen, S. |
| Faculty: | Medical Sciences |
| Date Deposited: | 01 Apr 2026 12:05 |
| Last Modified: | 01 Apr 2026 12:05 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/3912 |
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