Kyriskozoglou, Varvara (2024) Clinicopathological Features of Epstein-Barr Virus associated and Mismatch Repair Deficient Gastric Carcinomas. thesis, Medicine.
Full text available on request.Abstract
English Summary Each year around 1,000 people are diagnosed with stomach cancer in the Netherlands, one of the leading causes of cancer-related mortality worldwide. Carcinomas (GCs) make up for the majority of gastric malignancies and form a very heterogeneous group which researchers have recently divided into four types/subtypes based on their molecular and expression profile. Surgical removal is the only proven effective treatment to date, while there is growing evidence that dividing GCs based on their molecular characteristics may help identify new “targets” for targeted treatments such as immunotherapy and select patients whose prognosis might improve by the addition of peri-operative chemotherapy. This study focuses on Epstein Bar virus associated- (EBVaGC) and mismatch repair-deficient gastric carcinomas (dMMR/MSI GC), which have been associated with an extensive inflammatory response. We collected clinical and pathological data from patients treated at UMCG over the past 15 years and whose differential diagnosis in the biopsy or resection specimen included EBVaGC- and/or dMMR/MSI GC. Furthermore, tissue from these patients was stained for the T-lymphocyte co-receptor CD8 and for the macrophage/ histiocyte marker CD68. We demonstrated that patients with EBVaGC and dMMR/MSI GC had significantly more intra-tumoral CD8+ cells compared to patients with (pMMR/EBV-) GCs. Furthermore, analysis of the collected data showed that EBVaGC was more common in younger age, male gender and localization in the corpus, while dMMR/MSI GC was more often diagnosed in older, female patients and in the antrum. If our findings are confirmed by larger-scale studies, they could be relevant for the timely diagnosis of EBVaGC and dMMR/MSI GC and for tailoring treatment to individual patient and tumor characteristics.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Kats-Ugurlu, Dr. G. and Etten, Dr. B. van |
| Faculty: | Medical Sciences |
| Date Deposited: | 02 Dec 2025 14:51 |
| Last Modified: | 02 Dec 2025 14:51 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/3866 |
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