Brake, Maren (2024) The effect of ceramic-coated (hypoallergenic) total knee implants on physical functioning, pain, and health-related quality of life after Total Knee Arthroplasty in patients with metal hypersensitivity. thesis, Medicine.
Full text available on request.Abstract
Background: Total Knee Arthroplasty (TKA) offers a (cost-) effective treatment option for knee osteoarthritis. Although satisfaction rates are high after TKA, up to one-fourth of the patients experience dissatisfaction. One cause of unfavorable outcomes is metal hypersensitivity. For that, a ceramic-coated hypoallergenic implant may be an alternative. This study aims to gain insight into self-reported physical function, pain, and health-related Quality-of-Life (QoL) in metal-hypersensitive patients who received a primary or revision ceramic-coated implant. Methods: A retrospective cross-sectional cohort study. Physical functioning, pain, and health-related QoL were assessed using the Knee Injury and Osteoarthritis Outcome Score (KOOS), a numeric rating scale (NRS), the EuroQol 5-Dimension questionnaire (EQ-5D-5L) and the 36-Item Short Form Health Survey questionnaire (SF-36). Results were compared to normative values (standard primary TKA, standard revision TKA, and a general population), where possible. Results: Knee-specific functioning of the primary TKA study group (n=83) was comparable to that of standard primary TKAs and a general population, except for knee-specific QoL, which was scored lower by the study population. In the primary TKA study group, the results of the EQ-5D-5L and SF-36 regarding health-related QoL were contradicting. The revision TKA study group (n=7) scored worse than standard revision TKAs in almost all domains. Compared to standard primary TKAs or a general population, the outcomes suggest worse levels of physical functioning and QoL in that specific patient population. Conclusion: The primary TKA study group achieved similar knee-related functioning to standard primary TKAs and general populations. The revision TKA study group had consistently worse outcomes than standard revision or primary TKAs or a general population across all domains.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Seeber, Dr. Dr. rer. medic. G. H. (ScD), UMO, and Stevens, Dr. M. (PhD) |
| Faculty: | Medical Sciences |
| Date Deposited: | 29 Sep 2025 13:16 |
| Last Modified: | 29 Sep 2025 13:16 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/3827 |
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