Jspeerd, W. (2024) Relation between small airways disease and clinical relevant improvement in severe asthma patients treated with anti-interleukin-5 therapy. thesis, Medicine.
Full text available on request.Abstract
Introduction: The relation between small airways disease (SAD) and clinical outcomes after treatment with anti-IL-5(R) in severe asthma is not yet clear. We assessed the relation between improvement in SAD and patient related outcome measures after treatment with anti-IL-5(R) and whether the extent of small airways disease at baseline predicts clinical improvement. Methods: Ninety-two patients with severe asthma treated with anti-IL-5(R) for 4 months were included. Patients completed the Asthma Control Questionnaire (ACQ) and Asthma Quality of Life Questionnaire (AQLQ), as well as spirometry at the initial visit and the 4 month follow-up. SAD was defined as FEF25-75 values lower than the lower limit of normal. Associations between small airway values and questionnaire scores were analysed and adjusted for FEV1. Results: Improvement in SAD was related to improvement in both questionnaire scores (ACQ ρ=-0.249, p=0.017; AQLQ ρ=0.267, p=0.011). After adjustment for FEV1, improvement in SAD did not remain associated with improvement in questionnaire scores. Baseline SAD was not associated with improvement in both questionnaires. After adjustment for FEV1, more baseline SAD was associated with a higher increase in AQLQ scores (β=-0.128, p=0.037). Conclusion: Improvement in SAD is related to better asthma control and quality of life in severe asthma patients treated with anti-IL5(R). Patients with more SAD at baseline might have more improvement in quality of life. SAD is an important target for treatment in severe asthma, and the extent of SAD may be used to predict clinical response.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Dr. van der Meer, A.N. and Dr. Boudewijn, I.M. |
| Faculty: | Medical Sciences |
| Date Deposited: | 09 Oct 2024 12:05 |
| Last Modified: | 09 Oct 2024 12:05 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/3766 |
Actions (login required)
 |
View Item |