Idsardi, A.J. (2020) Long-term damage of radiotherapy for breast cancer: relating dosimetry of organs at risk with secondary malignancy-free survival. thesis, Medicine.
Full text available on request.Abstract
Background Early-stage detection for breast cancer (BC) caused more favourable tumours, now often treated with breast-conserving surgery and adjuvant radiotherapy. Improved radiation treatment techniques have prolonged overall survival of BC patients which caused the prevalence of BC survivors has increased. This increasing prevalence makes late side-effects of radiotherapy increasingly important. The aim of this study was to identify risk factors for secondary malignancies, one of the major late side-effects of radiotherapy. Methods A retrospective cohort study was performed including 4005 BC patients that received radiotherapy in the University Medical Center Groningen between 1-2005 and 12-2015. Clinical and follow-up data were sourced from patient charts and general practitioners. Radiation therapy dose-distribution data (dosimetry) was available for all patients. The main outcome was a secondary malignancy in either the contralateral breast or the ipsilateral lung. Statistical analysis was performed using both the Kaplan-Meier survival analysis and Cox proportional hazards. Results 12.1% of patients developed a secondary malignancy. The mean follow-up time was 76 months (range 0-172 months). The mean secondary malignancy-free survival for the contralateral breast was estimated to be 165.5 months. There were no significant predictors found for disease-free survival of a lung/breast secondary malignancy. Conclusion The amount of secondary malignancies of the contralateral breast and ipsilateral lung was too small to find significant predictors; the short follow-up of some cases might have contributed. There was no basis found to select patients at increased risk for secondary malignancies.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Dr. Crijns, A.P.G. |
| Faculty: | Medical Sciences |
| Date Deposited: | 30 Oct 2023 12:07 |
| Last Modified: | 30 Oct 2023 12:07 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/3717 |
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