Ertugrul, Imran (2020) Pre- and postconditioning the heart with hydrogen sulfide in vivo and ex vivo: a systematic review. thesis, Medicine.
Full text available on request.Abstract
Background: Preclinical studies have shown that preconditioning and postconditioning with hydrogen sulfide (H2S) exerts cardioprotective effects against myocardial ischemia-reperfusion injury (MIRI). We sought to evaluate these cardioprotective effects of H2S treatment across in vivo and ex vivo studies of MIRI using a comprehensive systematic review. Methods: Literature search of the electronic databases Medline, Embase and Cinahl was performed and the identified 1835 studies were subjected to our pre-defined inclusion criteria. Sixty-nine studies were considered eligible to be included and were grouped, based on the time of H2S application (pre- or postconditioning) and whether ischemia was locally or globally induced in the heart. Results: H2S treatment protected the heart against MIRI, with effect on outcome measures very relevant to the clinic. Systolic cardiac function (n=52) was the most commonly evaluated variable. Preconditioning with H2S in the setting of local ischemia resulted in 100% and in global ischemia in 67% of the studies in significantly improved systolic function in H2S treated groups versus the untreated groups. For postconditioning similar outcomes are reported with local ischemia in 85% and global ischemia 71% of the studies in significantly improved systolic function in H2S treated groups versus the untreated groups. These robust cardioprotective effects of H2S were also reported in measurements of infarct size, cardiac injury markers, diastolic cardiac function, workload and flow, oxidative stress and inflammation. Conclusions: In all studies reviewed, H2S treatment protected the heart from MIRI and showed advantageous effects with regard to cardiac function and injury markers, infarct size, apoptosis, inflammation and oxidative stress. Postconditioning with slowreleasing H2S donors offers a valuable opportunity for novel therapies within cardiac preservation for transplantation. Before clinical implication, studies evaluating the (long-term) effects of H2S treatment in large and female/mixed animal studies are needed.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | van Suylen, Drs. Vincent and van der Harst, Prof. dr. Pim and Erasmus, Dr. Michiel |
| Faculty: | Medical Sciences |
| Date Deposited: | 18 Sep 2023 11:19 |
| Last Modified: | 18 Sep 2023 11:19 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/3686 |
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