Eggels, S.C.J. (2020) EEN STUDIE NAAR HET ECHO-DOPPLER PROFIEL VAN DE DARMSLAGADERS GEDURENDE DE ZWANGERSCHAP, MET FOCUS OP HET MEDIAN ARCUATE LIGAMENT. thesis, Medicine.
Full text available on request.Abstract
Introduction: During human pregnancy multiple hemodynamic en anatomical changes occur within the mother, to facilitate the growth of the fetus. We hypothesize that due to these changes the end diastolic velocity and the peak systolic velocity of the blood will increase in the mesenteric arteries during resting conditions. If the increase in blood flow is not sufficient to support the increased metabolism of the female during pregnancy, pregnant women could complain of symptoms corresponding to intestinal ischemia. We started a transversal, observational, clinical trial to study the echo-Doppler profile of the mesenteric arteries during pregnancy. Due to the outbreak of COVID-19 virus it was not possible to complete the clinical trial. Therefore we were forced to switch to creating a one dimensional model, with which we could predict the peak systolic and end diastolic velocity of the coeliac artery and superior mesenteric artery in pregnant women. Methods: Pregnant women in different trimesters of the pregnancy were evaluated using splanchnic duplex ultrasound scanning. Later on in the internship we created a predictive, one dimensional model of the aorta, based on literature findings. With which we modulated duplex ultrasound measurements of 14 non-pregnant, female patiënts from an existing database to the expected duplex ultrasound measurements of these women during pregnancy. These measurements have been compared with the already included patiënts of the clinical trial. Results: There were no significant differences in the duplex ultrasound measurements between the already included pregnant women of the clinical trial and the modulated data, except for a decrease of the end diastolic velocity of the coeliac artery during expiration (P<0.001). Likewise there were no significant differences in the duplex ultrasound measurements between our own pregnant women and the modulated pregnant women, except for a decrease of the end diastolic velocity of the coeliac artery during expiration and an increase of the peak systolic velocity of the superior mesenteric artery during inspiration (P<0.05). Conclusions: The one dimensional model shows that the blood flow of the superior mesenteric artery increases during pregnancy. The blood flow of the celiac artery seems to decrease slightly.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Geelkerken, prof. dr. R.H. and Blauw, J. and Brusse-Keizer, M. and Groot Jebbink, E. and Baalman, J. |
| Faculty: | Medical Sciences |
| Date Deposited: | 15 Sep 2023 11:47 |
| Last Modified: | 15 Sep 2023 11:47 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/3685 |
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