Koorenhof, K. (Kirsten) (2017) The clinical added value of the Parkinson’s KinetiGraph (PKG): a retrospective study. thesis, Human Movement Sciences.
Full text available on request.Abstract
INTRODUCTION: The Parkinson’s KinetiGraph data logger (PKG) is a watch-like accelerometer that can serve as a tool to detect bradykinesia and dyskinesia over a period of 7 days, in patients with Parkinson’s disease (PD). Although this system is used worldwide, the clinical additional value has not yet been established. Therefore, we performed a retrospective study to investigate whether the PKG is practical and effective and as such indeed an addition for treatment practice. Clinical value was defined as applicability of both healthcare professionals perspective and patients perspective. METHODS: For patients that used the PKG, characteristics, treatment changes and motor function during clinical assessments (CA) were systematically collected from hospital records. PKG reports were analyzed on applicability (worn at least 5 days) and off-wrist time. RESULTS: In total, 39 patients were included (20 males). Of the applicable registrations (92.5%), the PKG was 1.66% of the time off-wrist. Both medication (28 changes in PD medication) and non-medication changes (13) were induced after the PKG registrations. Initially, median levodopa equivalent daily dose (LEDD) did not change shortly after the PKG registration, but increased from 1137.48 mg to 1167.75 mg within 4 months after the PKG. In 3 patients the initially induced treatment change was reversed within 4 months after the PKG. The number of immediate release levodopa (IR) users remained unchanged while dopamine agonist users increased from 22 to 24. The similarity between the PKG and CA was 83.3% for tremor, 81.1% for bradykinesia and 62.2% for dyskinesia. CONCLUSION: This study showed that the PKG is handled well by patients, and PKG registrations seemed to induce medication changes. However, considering the discrepancies between CA and PKG, the clinical added value of the PKG is questionable. Further multi-center research is needed to get a better view.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Kamsma, dr. Y.P.T. and Stuijt, C.C.M. and Laar, prof. dr. T. van |
| Date Deposited: | 06 May 2022 13:03 |
| Last Modified: | 06 May 2022 13:03 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/3248 |
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