Huiting, W. (Wouter) (2014) Whole Body Vibration Increases Cholinergic Activity And Synaptic Vesicle Density In Young C57BL6 Mice. thesis, Human Movement Sciences.
Full text available on request.Abstract
Whole Body Vibration (WBV) is a promising intervention to increase muscle strength, bone mass and balance in elderly subjects. Recent unpublished studies suggest that WBV might also be able to induce increased learning and memory in young and aged mice, comparable to the effects of active physical exercise. To further uncover the mechanisms through which WBV could act on cognition, a 5-week WBV intervention was introduced to young adult C57Bl6 mice (n=80), divided over 10 groups. The 5 experimental groups received WBV for 10 minutes a day, 5 days a week. After each week a home cage control group and an experimental group were sacrificed. Brain samples were stained for the cholinergic marker choline acetyltransferase (ChAT) and for the presynaptic vesicle marker synaptophysin. ChAT and synaptophysin presence in the mouse hippocampi was evaluated using a Quantimet© system. Mice that received 5 weeks of WBV showed significantly higher levels of ChAT in the dentate gyrus, CA1- and CA3 region compared to controls, but not in the stratum lucidum. They also showed significantly higher levels of synaptophysin in the dentate gyrus, CA1 region and stratum lucidum compared to controls. Together, these results suggest that 5 weeks of WBV increases cholinergic activity and synaptic vesicle density in C57Bl6 mice, which could represent an increased capacity for learning and memory functions.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Heuvelen, dr. M.G.J. van and Zee, prof. dr. E.A. van der |
| Faculty: | Medical Sciences |
| Date Deposited: | 01 Apr 2022 12:42 |
| Last Modified: | 01 Apr 2022 12:42 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/3023 |
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