Visser, K. (Koen) (2021) Serum free thiols are potential biomarkers of oxidative stress following traumatic brain injury. thesis, Medicine.
Full text available on request.Abstract
Background: Excessive oxidative stress is believed to precipitate long term disability following traumatic brain injury (TBI). The concentration of serum free thiols (an important group of antioxidants) has been shown to reflect the production of oxidative stress in many diseases. This exploratory study aimed to determine the concentrations of serum free thiols in the acute phase after TBI as well as the capacity of serum free thiols to act as a prognostic biomarker. Methods: Inclusion criteria for this retrospective observational study were: TBI of any severity, an available blood sample obtained within 24 hours of admission, head computed tomography data, and functional outcome measurement at six months post-TBI. Concentrations of serum free thiols in TBI were first compared to levels in healthy controls. Next, the association between free thiols and admission characteristics (e.g. injury severity score, age, and gender) was evaluated. Finally, binary logistic regression was used to assess the prognostic capability of this marker for functional recovery at six months post-TBI. Results: Mean serum free thiol concentrations were significantly lower in TBI (n = 77) compared to healthy controls (n = 55) (mean (standard deviation) 210.3 (63.3) vs. 301.8 (23.9) μM, P < 0.001). The injury severity score was strongly correlated the levels of serum free thiols (P < 0.001). Concentrations of serum free thiols were higher in patients with complete recovery than in incomplete recovery, suggesting that in patients with complete recovery less oxidative stress is generated in the acute phase post trauma. Conclusion: We present serum free thiols as a novel biomarker of oxidative stress after TBI. Future studies need to validate our findings and expand the applicability and on the prognostic capability of this marker.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Naalt, prof.dr. J. van der (Joukje) |
| Faculty: | Medical Sciences |
| Date Deposited: | 06 Jan 2022 08:32 |
| Last Modified: | 06 Jan 2022 08:32 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2956 |
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