Veen, H.N. van der (2019) Renal resistive index can predict acute kidney injury in intensive care patients. thesis, Medicine.
Full text available on request.Abstract
Objective: this sub-study investigated the possible association between the Renal Resistive Index (RRI) and the development of Acute Kidney Injury (AKI) in intensive care patients. Method: this study was conducted in the Intensive Care Unit of the University Medical Centre of Groningen from May 2018 till May 2019. All acutely admitted patients, with the exception of neurological patients, were included. Critical care ultrasonography (CCUS) and biochemical analysis were performed on day one, three and five. RRI was measured as (peak systolic velocity – end diastolic velocity) / peak systolic velocity. AKI was defined according the KDIGO criteria. Univariate- and multivariate analyses were performed to test for associations with the occurrence of AKI. Outcomes were considered significant when P<0.05. Results: a total of 305 patients were included. A total of 136 patients (45%) fulfilled the criteria for AKI within five days after admission, including 70 patients (23%) with AKI stage 1; 29 patients (9.5%) with AKI stage 2; and 37 patients (12%) with AKI stage 3. Patients with AKI had a higher RRI on day one than those without: 0.68 (±0.10) vs 0.66 (±0.10). Patients with AKI stage one specifically also had a higher RRI on day one and five compared to patients without AKI: 0.69(±0.09) vs 0.66 (±0.10) and 0.75 (±0.06) vs 0.68 (±0.09) respectively. RRI was not associated with AKI in univariate analysis. Secondarily, RRI at day one was significantly associated AKI stage one (OR 1.03, 95%CI 1.00 – 1.06) in univariate analysis. This association remained significant after multivariate analysis (OR 1.03, 95%CI 1.00 – 1.07). In a second multivariate analysis, addition of the variables increase and decrease in RRI did not improve prediction of AKI. Conclusion: There was a significant association between the RRI at day one and the development of AKI stage 1 within five days after ICU admission. Addition of RRI in increase and decrease did not improve prediction of AKI.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Koeze, J. |
| Faculty: | Medical Sciences |
| Date Deposited: | 17 Sep 2020 11:46 |
| Last Modified: | 17 Sep 2020 11:46 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2765 |
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