Kornmann, N.S.S. (2012) Phenotype of Dupuytren disease : Patterns of combination of affected fingers in relation to severity of the disease. thesis, Medicine.
Full text available on request.Abstract
INTRODUCTION Dupuytren disease is a fibroproliferative condition affecting the palmar fascias of the hand and fingers characterized by a variable expression and an unpredictable course. Little is known about patterns of the disease and if certain combinations occur only in severe disease. The aim of our study was to try to identify such patterns. We hypothesized that there is a relation between the affected rays and the severity of the disease, whereby the fourth and fifth digit are most frequently affected and that an affected thumb or first web space is associated with a severe contracture of fourth and fifth finger. METHODS Photographs and measured extension deficits of 531 hands were studied and each ray was assessed according to the classification of Iselin. Frequency tests were performed to see if certain combinations of Dupuytren affected rays occurred more often than others. Fisher’s exact test was performed to study the association between severe contractures of ring and little finger and an affected radial side. A multivariate logistic regression was performed to adjust for possible confounders. RESULTS We found 25 different patterns of affected rays. Most frequently presented patterns were: an affected ring and little finger, an affected middle, ring and little finger and an affected middle and ring finger. Univariate analysis showed a significant association between radial involvement and a severe contracture of ring and little finger. In multivariate analysis this significance disappeared. Furthermore, we found an association between alcohol consumption, radial side involvement and a severe contracture of ring and little finger. CONCLUSION This study gives an overview of patterns in Dupuytren disease, and shows in particular that excessive alcohol use has a possible influence on a severe contracture of ring and little finger, especially in patients with an affected thumb.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Facultair begeleider: and Werker, Prof. dr. P.M.N. and Medebegeleider: and Lanting, R. Msc and Locatie: plastische chirurgie, UMCG |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 11:06 |
| Last Modified: | 25 Jun 2020 11:06 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2580 |
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