Angiogenic biomarkers and their role in cardiovascular risk in womewith a history of hypertensive disorders of pregnancy orspontaneous preterm birth

Zwager, C.L. (2016) Angiogenic biomarkers and their role in cardiovascular risk in womewith a history of hypertensive disorders of pregnancy orspontaneous preterm birth. thesis, Medicine.

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Abstract

Background: Hypertensive disorders of pregnancy (HDP) and spontaneous preterm delivery (sPTD) are independent cardiovascular (CV) risk factors for the mother. Mechanisms linking HDP and sPTD with subsequent CV disease remain unclear. Potential roles have been suggested for endothelial dysfunction and anti-angiogenic biomarkers. The aim of this study was to assess levels of circulating angiogenic and endothelial markers and associations of these markers with CV parameters in women with previous HDP and sPTD, 5-12 years postpartum. Methods: Concentrations of plasma soluble endoglin (sEng), soluble fms-like tyrosine kinase-1, vascular endothelial growth factor, and serum soluble (s)ESelectin, tumor necrosis factor-a and interleukin-8 were determined by Enzyme Linked Immunoassays on a total of 268 women (n=164 HDP, n=29 sPTD). Concentrations were compared across pregnancy characteristics, and associations between angiogenic markers and CV parameters were assessed. Results: Women with a history of HDP had higher sE-Selectin concentrations than women with a previous normotensive pregnancy. sE-Selectin was positively associated to mean arterial pressure, diastolic blood pressure, and negatively associated with HDL cholesterol. Women with a history of sPTD had higher sEng levels when compared to women who delivered term. Conclusion: Women with a previous HDP exhibited endothelial activation years after pregnancy. Women with a history of HDP and higher sE-Selectin levels were more likely to have cardiac concentric remodeling, higher blood pressure and adverse metabolic changes. Women with a previous sPTD exhibited an enhanced antiangiogenic state.

Item Type:	Thesis (Thesis)
Supervisor name:	Faculty supervisor at UMCG: and Meer, Dr. P. van der and GIPS-M supervisor: and Kallenberg, Prof. C.
Supervisor name:	Local supervisors at CCRF: and Leeson, Prof. P. and Boardman, Dr. H. and Lewandowski, Dr. A. and Department: Cardiology and Institute: Cardiovascular Clinical Research Facility (CCRF) and John Radcliffe Hospital, University of Oxford
Faculty:	Medical Sciences
Date Deposited:	25 Jun 2020 11:05
Last Modified:	25 Jun 2020 11:05
URI:	https://umcg.studenttheses.ub.rug.nl/id/eprint/2520

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