Kors, E.J. (Elizabeth Janine) (2014) Clinical outcome of respiratory viral infections in children with cancer, fever and neutropenia. thesis, Medicine.
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Abstract
Introduction The role of respiratory viral infections (RVI) in fever and neutropenia (FN) episodes in children with cancer has been less characterized than bacterial infections. Clinical outcome between different respiratory viruses (RVs) is unknown in this population. Aims To compare the clinical outcome of a sole RVI caused by different RVs and comparing a sole RVI versus a respiratory viral co-infection in children with cancer and FN. Methods: Prospective, multicenter, cohort study in children with cancer and FN admitted to five hospitals in Santiago, Chile between May 2009 and August 2013. Children were evaluated by clinical examination, laboratory tests, bacterial cultures and a nasopharyngeal sample was obtained for the detection of 17 RVs using PCR. Clinical outcome variables were collected. Results A total of 578 episodes of FN were enrolled of whom 54% were male, 49% had leukemia as underlying malignancy and the median age was 7 years. A RVI was detected in 33%. No pathogen was detected in 35% of the episodes, a sole bacterial infection was found in 15%, and a mixed viral-bacterial infection in 15%. Most detected RVs were respiratory syncytial virus, rhinovirus, parainfluenza virus, influenza virus and bocavirus. Clinical outcome in terms of days of hospitalization, days of fever, days of neutropenia, O2 requirement, admission to the pediatric intensive care unit and death rate was similar in between different sole RVI’s and also when comparing sole RVIs versus co-RVIs. Conclusions To our knowledge this is the first report comparing clinical outcome between different RVs causing FN episodes in children with cancer. Our data showed a favorable outcome in all RVI episodes, including sole and co-RVIs
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Smits, Drs. P.J.H. and Ziekenhuisgroep Twente |
| Supervisor name: | Torres, Dr. J.P. and Dr. Luis Calvo Mackenna and Santiago, Chile |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 11:02 |
| Last Modified: | 25 Jun 2020 11:02 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2234 |
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