Teeseling, L. van (Lisa) (2017) SANDWICH : Skin Advanced glycation endproducts in Normal WeIght CHildren. thesis, Medicine.
Full text available on request.Abstract
Introduction Advanced glycation endproducts (AGEs) are associated with the pathogenesis of complications caused by chronic illnesses, e.g. diabetes and obesity. AGEs can be measured non-invasively with skin autofluorescence (SAF), using the AGE Reader®. Data on SAF levels for the pediatric population in the Netherlands are limiting, therefore the aim of this study was to obtain reference data in normal weight children. In addition, the correlations between SAF level and age, gender, and skin type were evaluated. Material and methods A cross-sectional study was performed in children (4-18 years of age) with normal weight, defined as body mass index standard deviation score (BMI-SDS) > -1.1 and <1.1. Participants were classified in the following age-categories: <10, ≥10 – <13, ≥13 – <15, ≥15 – <17, and ≥17 – <19. AGEs were measured with SAF, using the AGE Reader®. Furthermore, skin type was recorded, according to the Fitzpatrick scale and categorized in white (skin type I-II) and non-white skin (skin type III-VI). Results A total of 529 children was included of which 428 were analyzed, with a mean age of 11.58 ± 3.84 years and mean SAF level of 1.19 ± 0.24 arbitrary units (AU). A significant difference was observed on SAF level between the age categories (p=0.010). Children aged < 10 had significant higher SAF levels (p=0.048) and a higher relative risk on high SAF levels, compared to children aged ≥10 – <13 (RR 0.27 (0.10-0.69), p=0.006). There was no significant correlation between SAF level and age category (r= -0.057, p=0.236). Skin type was weakly correlated with SAF level (r=0.202, p<0.001) and non-white skin type had a significant 5-fold increase in relative risk of high SAF levels (RR 5.07 (2.39-10.76), p<0.001). No correlation was observed between SAF level and gender. Conclusion This study provides reference values of SAF levels for the normal weight pediatric population in the Netherlands. The data can be used as comparison for chronic ill children to objectify the risk of development of complications. Influence of age and gender on SAF was not observed, but skin type seems to be associated with SAF. Further research is warranted to evaluate the effect of food on AGEs and SAF level and to define exact reference ranges for children.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Faculty supervisor: and Bakker-van Waarde, Dr. W.M.pediatrician-endocrinologist |
| Supervisor name: | Vorst, Dr. M.M.J. van der pediatrician-clinical pharmacologi and Lentferink, Drs. Y.E. PHD student |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 11:01 |
| Last Modified: | 25 Jun 2020 11:01 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2169 |
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