Nasrollah, M. (Mahtab) (2015) Changing of Quality of Life in patients with laryngeal and hypopharyngeal carcinoma undergoing primary (chemo)radiation or primary surgery followed by postoperative (chemo)radiation. thesis, Medicine.
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Abstract
Introduction: Organ preservation protocols are preferred as better QoL is assumed. This assumption is not yet thoroughly investigated. Objective: The primary aim is to compare QoL of patients with stage III and IV laryngeal- and hypopharyngeal cancer treated with (C)RT and those treated with TLE and postoperative (C)RT. Study design and study population: A retrospective observational cohort study performed on a prospectively built database containing stage III and IV laryngeal- and hypopharyngeal cancer treated with primary (C)RT and those treated with primary TLE and postop (C)RT. Main study parameters: The questionnaires, EORTC QLQ-H&N35 and QLQ-C30, which have been used for collecting quality of life data at the time points: baseline, 1, 2, 3, 4, 5, 6, 7 and 12 weeks, and 6, 12, 18 and 24 months. Results: 33 patients were excluded. No difference in global QoL score was found in the EORTC QLQ-C30 questionnaire. However, the EORTC QLQ-H&N35 questionnaire showed difference during the (C)RT treatment period, in the favor of the (C)RT only patients. Discussion/conclusion: there were some limitations, more investigations is needed.
Item Type: | Thesis (Thesis) |
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Supervisor name: | Supervisor: and Langendijk, Prof. dr. JA and Department of Radiation Oncology and University Medical Center Groningen |
Faculty: | Medical Sciences |
Date Deposited: | 25 Jun 2020 11:00 |
Last Modified: | 25 Jun 2020 11:00 |
URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2032 |
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