Davina, A. (Anne) (2015) Proton pump inhibitor associated Hypomagnesemia in Diabetes Mellitus type 2. thesis, Medicine.
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Abstract
Background: Hypomagnesaemia in diabetes mellitus type 2 (DM2) patients is linked to poorer glycemic control and a higher prevalence of complications. Various studies have shown that proton pump inhibitors (PPIs) may cause hypomagnesemia, but conclusive evidence is missing. Objective: In this study we investigate the association between PPI use and the risk of hypomagnesemia in DM2 patients. Methods: A cross-sectional cohort study was done in the ZGT Almelo under 322 DM2 patients> 18 years. Hypomagnesaemia was defined as serum magnesium <0.70mmol/L. PPI use, demographic data, other medication use, kidney function, proteinuria, serum electrolytes, cholesterol, triglycerides, urinary excretion of electrolytes and complications were analyzed additionally. Results: Of all patients, 16% had hypomagnesemia. These patients did not use significantly more PPIs; 45.1% vs 32.1% (p = 0.073). In the multivariate regression analysis, the association between PPI use and hypomagnesemia was borderline significant (OR = 1.91; 95% CI: 0.95 - 3.83; P = 0.067) Conclusion: The prevalence of hypomagnesemia in the DM2 population is high. The association between hypomagnesemia and PPI use is borderline significant. Further research is necessary to elucidate this relationship. In view of the negative effects of hypomagnesaemia, we recommend that magnesium levels in DM2 patients should be determined in case of symptoms consistent with hypomagnesemia, especially in those patients using PPIs.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Begeleider: and Laverman, dr. G.D. and ZGT Almelo and Afdeling interne geneeskunde |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:59 |
| Last Modified: | 25 Jun 2020 10:59 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/1950 |
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