Kuilder, G. (Gerlinda) (2015) Een retrospectieve studie naar het effect van groene groenten, rundvlees, volle melk en roomboter op de lengtegroei van kleine kinderen. thesis, Medicine.
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Abstract
Background In the Netherlands the average adult male is 183,8 cm (with an SD of 7,1 cm), and the average adult woman is 170,7 cm (with an SD of 6,3 cm), but not everyone reaches this length. In children 'short stature' is a common problem. In 80% of these cases this is a normal growth variant without underlying pathology, also referred to as idiopathic short stature (ISS), wherein no effective treatment is available at this moment. In the last 150 years the average height of both female and males increased in most Western countries. The improvement of nutrition, in both quantity and quality is seen as a major cause, although a direct relationship is difficult to prove. A question that arises from this observation is whether a optimization of the amount of nutrients in food, at a constant calorific value, can have a positive effect on the growth of children with ISS by using a specific dietary advice. This is what has been examined in this retrospective cohort study. Methods Between January 2008 till June 2013 children were selected from the Ziekenhuisgroep Twente (ZGT) database with an age of ranging between 2 and 12 years and an SDS-line between ≤ -1 and ≥ -3 according to the TNO growth curve and in which a minimum of 2 length measurements were within a period of 18 months. After applying the exclusion criteria, the research group was formed. An intervention group was then drafted with children who had received the nutritional advice and a control group with the other children who were eligible for this study. Subsequently, an intention-to-treat analysis was performed and next to that a sub-analysis was performed in which the intervention group consisted of children who actually followed the dietary advice for a minimum of 12 months for more than 50% and a separate control group with the other children. For statistical analysis SPSS version 20.0 was used. Results The intention-to-treat analysis showed an increase in height-SDS in the intervention group after 18 months of follow-up, where the control is seen almost no change. The difference in growth of 0,17 SDS between the two groups is significant (p = 0,049). After a follow-up of 30 months there was still a significant difference in height-SDS of 0,45 SDS (p = 0,038). Subsequently, the sub-analysis revealed an increase in the height-SDS in the intervention group both after 18 and 30 months follow-up. In the control group, the height-SDS remained unchanged both after 18 and 30 months follow-up. Conclusion A nutrient-rich diet with age-appropriate portions of green vegetables, beef, full-fat milk and full-fat butter has a proven positive effect on height growth in small children aged from 2 to 12 years. Therefore, a dietary advice may play a role in the treatment of short stature in children (ISS), where there is no pathology involved and for which no other therapy is available. In addition, this dietary advice also has a proven beneficial effect on the immune system and lipid profile. As a last it proves to be cost-effective and it is an intervention that is relative easy to implement without any known side effects.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Facultair en Dagelijks begeleider: and Gaag, drs. E. van der and Instelling: Ziekenhuis Groep Twente, locatie Hengelo and Afdeling Kindergeneeskunde |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:59 |
| Last Modified: | 25 Jun 2020 10:59 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/1943 |
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