Staveren, G. van (Gerdia) (2013) De invloed van anticholinerge en sederende medicatie op de cognitieve en fysieke fitheid van mensen met dementie. thesis, Medicine.
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Abstract
Background: Dementia is a common syndrome that mainly affects the elderly over 60 years. Dementia not only causes cognitive decline, it also affects physical functions. Several studies revealed positive effects of physical activity on cognition and physical functions of healthy elderly. For elderly with dementia, these findings are still inconsistent. This is possibly due to confounding factors, such as medication use. Especially drugs with anticholinergic and sedative effects may influence cognitive and physical abilities. The effect of anticholinergic and sedative drugs on both cognitive and physical abilities of demented elderly have not been studied yet. Therefore, in this study, the main questions are: “Do anticholinergic and sedative drugs influence cognitive and physical fitness in persons with dementia, and do these drugs influence the effect of a physical intervention in persons with dementia?” Method and results: Data has been collected from 126 elderly with dementia (mean age: 85 yr; women: 79%; mean MMSE score: 16,5), living in nursing homes in and around Groningen. Cognitive and physical tests have been conducted from these participants. Daily anticholinergic and/or sedative medication use of every individual has been summarized in a Drug Burden Index (DBI). The correlations between the DBI and the cognitive and physical tests were non-significant. Also, no significance was found in multiple regression analyses between DBI and these tests. Finally, correlations between the DBI and progression in cognitive and physical tests after a physical intervention showed no significance. Conclusion: From this study, it cannot be concluded that the use of anticholinergic and sedative drugs influence cognitive and physical abilities in nursing-home residents with dementia. It also cannot be concluded that these drugs influence outcomes in cognitive and physical function after a physical intervention. This study shows no evidence that anticholinergic and sedative medication use must be considered as confounders in studies focusing on cognition and physical abilities in nursing-home residents with dementia. Further research is required for testing these conclusions.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Heuvelen, Dr. M.J.G. van and Hortobágyi, Prof. Dr. T. and Bossers, Drs. W. and Boersma, Dr. F. and Klein, Dr. H.C. and Taxis, Prof. Dr. K. |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:57 |
| Last Modified: | 25 Jun 2020 10:57 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/1742 |
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