Mesothelioma. Volume quantification of malignant pleural mesothelioma.

Bronsveld, T. (Thomas) (2015) Mesothelioma. Volume quantification of malignant pleural mesothelioma. thesis, Medicine.

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Abstract

Purpose: The prognosis of malignant pleural mesothelioma (MPM) is poor and most prognostic factors are inconsistent. PET/CT provides a measure of the metabolic activity of the tumor. Therefore, we evaluated the prognostic value of parameters derived from PET/CT, produced by our new developed tool. Methods: PET/CT images of 38 patients, from three institutions, with MPM who underwent PET/CT prior to treatment were retrospectively semi-automatically analyzed. The measured PET parameters included; mean, maximum and peak standardized uptake values (SUV), metabolic tumor volume (MTV) and total lesion glycolysis (TLG, the tumor volume multiplied by its mean SUV). And multiple clinical variables were included. Results: Median survival was 9.9 months after diagnosis. Univariate Cox regression showed that SUVmax (HR=1.05), SUVpeak (HR=1.05), TLG (HR=1.15) and MTV (HR=1.13) are significant predictors for overall survival. No clinical variables turned out to be significant. Kaplan-Meier analyses showed significant difference in survival when MTV and TLG were grouped based on their median value. Conclusion: A new developed software tool showed that SUVmax, SUVpeak, TLG and MTV are all significant PET/CT parameters to predict survival in patients with malignant pleural mesothelioma. A prospective study should be performed to assess the possibility for chemotherapy response monitoring using this tool.

Item Type:	Thesis (Thesis)
Supervisor name:	Schouwink, Dr. J.H. and Medisch Spectrum Twente Enschede
Faculty:	Medical Sciences
Date Deposited:	25 Jun 2020 10:57
Last Modified:	25 Jun 2020 10:57
URI:	https://umcg.studenttheses.ub.rug.nl/id/eprint/1714

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