Laan, M. van der (Martin) (2011) Microbiologische evaluatie van het gebruik van een chloorhexidine spoelmiddel tijdens de chirurische behandeling van peri-implantitis. thesis, Dentistry.
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Abstract
Introduction The number of implants used in dental clinics is continuously increasing. Since periimplantitis is known as a frequently occurring complication, there is an urgent need for a reliable treatment. Surgical exploration in combination with mechanical scaling of the dental implant surface and chemical decontamination with a chlorhexidine solution is often used for the treatment of peri-implantitis. No evidence is available for which could be an effective treatment for peri-implantitis. The goal of this study is to examine the clinical effect of the use of a 0.12% chlorhexidine + 0.05% CPC solution during surgical treatment of periimplantitis in comparison with rinsing the implant surface with a placebo solution. Methods In this clinical study 30 patients participated. The patients were randomly assigned to a test group and a control group. All patient received apically positioned flap surgery followed by mechanical scaling and rinsing with a 0.12% chlorhexidine + 0,05% CPC {Perio-aid®) solution {test group) or a placebo solution {control group). A microbiologic sample was taken at 4 moments; at baseline {TO), at two moments during surgery: before {Tvoor) and after {Tna) mechanical and chemical cleaning, and 3 months after surgical treatment {T3). The Mann Whitney U Test and de Wilcoxen Signed Rank Test were used to analyze continuous variables {total detectable bacterial load). The Chi Square Test en de Me Nemar Test were used to analyze dichotome variables {frequency of detection of para-pathogens). Results Both the control group and the test group consisted of 15 patients. The control group consisted of 48 dental implants with peri-implantitis and the test group of 31 dental implants. At baseline {TO) no significant differences were observed between both groups. Analyzing the microbiological composition of the biofilm of the dental implant surface both the treatment for the control and the test group showed a significant positive effect (p < 0.001). The results of the test group at T3 were significantly better than the control group (p < 0.05}. Analyzing the microbiological composition of the peri-implant sulcus gave at TO and T3 no significant differences. Conclusion A short-term significant positive effect is observable for rinsing the implant surface with a 0.12% chlorhexidine + 0.05% CPC solution {Perio-aid®) during surgical treatment of periimplantitis compared to rinsing the implant surface with a placebo solution. Three months after treatment no significant effect is observable. It is not clear whether this microbiological effect will lead to better clinical results in peri-implantitis treatment.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Waal, Drs. Y.C.M. de |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:40 |
| Last Modified: | 25 Jun 2020 10:40 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/167 |
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