Contact dermatitis in children with and without atopic dermatitis: which are the frequent allergens?

Lubbes, S. (Stefanie) (2014) Contact dermatitis in children with and without atopic dermatitis: which are the frequent allergens? thesis, Medicine.

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Abstract

Background. Data on contact dermatitis in children is poor. This study aims to identify the occurrence of contact dermatitis in children. This will allow better identification of potential sensitizers and improve patients’ care in children. Methods. We retrospectively analyzed data of patients aged 0-17 years, that were patch tested with at least the European baseline series between 1996-2013 in three University Hospitals across the Netherlands. Results. 1012 Children (male 37%, mean age 13 years) were included, of which 469 (46%) developed ≥1 positive reactions. The most frequent reactions were found to nickel (16.4%), cocamidopropyl betaine (15.9%), fragrance mix I (9.9%), amerchol L-101 (8.8%) and wool alcohols (6.2%). Children with atopic dermatitis reacted significantly more frequent to wool alcohols (p<0.04), amerchol L-101 (p<0.04) and fragrances compared to children without atopic dermatitis. Strikingly, significantly less positive reactions to wool alcohols, fragrances and caine mix were found testing with the TRUE-test compared to chamber patch test preparations. Conclusion. Cocamidopropyl betaine frequently has positive reactions in children. Atopic dermatitis is a risk factor for developing reactions to wool alcohols and fragrances. Especially in children with recalcitrant atopic dermatitis, contact dermatitis caused by these allergens should be considered. The difference in positive reactions to important allergens between TRUE test and chamber patch test preparations is striking and needs further investigation. This observation is especially important as the TRUE test is easy to use in children, and these allergens could therefore be missed in this population.

Item Type:	Thesis (Thesis)
Supervisor name:	Schuttelaar, Dr. M.L.A.
Supervisor name:	Middelkamp Hup, Dr. M.A. and AMC and Rustemeyer, Dr. T. and VUmc
Faculty:	Medical Sciences
Date Deposited:	25 Jun 2020 10:55
Last Modified:	25 Jun 2020 10:55
URI:	https://umcg.studenttheses.ub.rug.nl/id/eprint/1603

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