Bosch, T. (Tessa) (2019) Perinatal risk factors and General Movements could partly predict the behavioural and cognitive outcome of very preterm born children at the age of 2. thesis, Medicine.
Full text available on request.Abstract
The exact prevalence of behavioural and cognitive problems in very preterm born children is unknown. The primary aim of this study was to determine the prevalence of behavioural and cognitive problems at the age of 2 in children born at less than 30 weeks and/or with a birth weight less than 1000 grams. The secondary aim was to determine whether perinatal factors and quality of general movements (GMs) were associated with worse outcomes. We included 85 children in this study with as endpoints Child Behavior Checklist (CBCL) scores and cognitive indexscores of the Bayleys Scales of Infant and Toddler Development. Perinatal characteristics of 85 children were collected and GMs of 63 children at the corrected age of 3 months were scored. The associations between perinatal factors, GMs and behaviour and cognition were analysed using independent samples T-tests and uni- and multivariate linear regression analyses. In our group only 1-4% scored a clinical relevant CBCL score. The median cognitive index score was 96 (with p25-p75 of 87-102). The only perinatal factor which significantly (p<0.05) predicted behaviour was sex, where boys performed better. Moreover we found trends towards an association (p<0.1) with sepsis, treatment with dexamethasone and IVH. Birthweight, SES and IVH grade 3-4 were significantly (p<0.05) associated with lower cognitive scores. Exploring the GMs, we found a significant association between a monotonous movement character and higher (i.e. poorer) total CBCL scores (univariate linear regression, p=.029). In conclusion, children in our cohort had very few problems with behaviour and cognition. The most striking results were that boys had better behavioural scores than girls and that a monotonous movement character in the assessment of GMs is a really important factor to consider for poorer behavioural scores.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Faculty supervisor: and Bos, A.F. and Location: and Department of neonatology and University Medical Center of Groningen |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:55 |
| Last Modified: | 25 Jun 2020 10:55 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/1589 |
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