Heistein, J. (Julia) (2012) The effect of delayed cord clamping on haematological status in low birth weight infants : A randomised controlled trial in Stanger, South Africa. thesis, Medicine.
Full text available on request.Abstract
OBJECTIVES: To evaluate whether delayed cord clamping (DCC) is effective in improving the haematological status of low birth weight infants in a middle-income country, and whether this is associated with an increased risk of adverse effects in mothers or infants. METHODS: Women who were expected to deliver a low birth weight infant (as measured by a symphysal-fundal height ≤34 cm) in Stanger Hospital, South-Africa, were randomly assigned to receive early (within 1 minute) or delayed (between 2 and 3 minutes) umbilical cord clamping. Infants were reassessed at 24 hours (n=104) and 2-3 months after birth (n=68). RESULTS: Delayed compared to early cord clamping (ECC) resulted in a higher mean haemoglobin (18.0 g/dL v 16.9 g/dL, p=0.014) and haematocrit (0.460 L/L v 0.490 L/L, p=0.013) 24 hours after birth. Mean bilirubin levels after 24 hours were comparable between groups (DCC 94 μmol/L v ECC 83 μmol/L, p=0.570). Eight (14%) ECC infants and two (4%) DCC infants required phototherapy. Polycythaemia or postpartum haemorrhage did not occur. At the follow-up 2 to 3 months after birth, there were no differences in mean haemoglobin levels (DCC 9.9 g/dL v ECC 9.8 g/dL, p=0.626), iron status, or prevalence of anaemia (DCC 34% v ECC 42%, p=0.452) between groups. CONCLUSION: Despite evidence of successful placental transfusion on the first day after birth, a beneficial effect of DCC on the haematological status of low birth weight infants could not be detected 2 to 3 months later. These results, however, may be biased by a high attrition rate. DCC was not associated with increased adverse events.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Supervisors: and Rheenen Dr. P. van & and Tiemersma, Drs. S. and Maternity & Paediatrics department and Stanger Provincial Hospital, Stanger |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:40 |
| Last Modified: | 25 Jun 2020 10:40 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/158 |
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