Development of 64Cu-labeled radiopharmaceuticals for neuroendocrine tumor detection with positron emission tomography :A comparison between 64Cu-NODAGA-NOC, 68Ga-NODAGA-NOC and 68Ga-DOTA-TOC

Schreuder, R.S.B.H. (2017) Development of 64Cu-labeled radiopharmaceuticals for neuroendocrine tumor detection with positron emission tomography :A comparison between 64Cu-NODAGA-NOC, 68Ga-NODAGA-NOC and 68Ga-DOTA-TOC. thesis, Medicine.

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Abstract

Neuroendocrine tumors (NETs) are a heterogeneous group of neoplasms. which can be spread over the whole body. This provides a real challenge for diagnosing the disease based on symptoms, laboratory tests and physical examination. For that reason, diagnosis and location of these diseases are often obtained based on metabolic activity shown by molecular imaging techniques by means of positron emission tomography and radiotracers. Literature has described radioactive copper-64 (64Cu) as a suitable PET tracer for NETs. The advantage of 64Cu is based upon its longer half-life (12.7 hours), but also because of its ideal nuclear characteristics making this tracer useful for both detection and therapeutic purposes. The main goal of this research was investigating whether a 64Cu-labeled radiotracer is a suitable radiotracer for detecting neuroendocrine tumors in comparison to the currently used gallium-68 (68Ga) labeled radiotracers. To achieve this goal, synthesis of reference samples and radioactive 64Cu-labeled and 68Ga-labeled radiotracers were performed. Lastly, stability and displacement assays were also performed to study the pharmacokinetics of the tracers. Despite the successful synthesis results of the compounds and the in vitro results, it is difficult to make an accurate prediction whether 64Cu-NODAGA-NOC is a suitable PET tracer for NETs. Additional research and repetition of the performed experiments is needed to accomplish a reliable and accurate comparison between the different radiotracers.

Item Type:	Thesis (Thesis)
Supervisor name:	Faculty supervisor: and Luurtsema, Dr. G. and University Medical Centre Groningen and Department for Nuclear Medicine and Molecular Imaging
Faculty:	Medical Sciences
Date Deposited:	25 Jun 2020 10:53
Last Modified:	25 Jun 2020 10:53
URI:	https://umcg.studenttheses.ub.rug.nl/id/eprint/1362

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