Rakic, J. (2012) NSAID intake using ASAS-NSAID score in ankylosing spondylitis. thesis, Medicine.
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Abstract
Introduction: The aim of this study was to analyse non-steroidal anti-inflammatory drug (NSAID) use, during the first year of tumour necrosis factor- alpha blocking therapy (anti-TNF therapy) and to compare this to 1-year follow-up of ankylosing spondylitis (AS) patients without anti-TNF treatment. Methods: Prospective cohort study of 248 AS outpatients who started anti-TNF therapy and 92 AS outpatients without anti-TNF therapy. Clinical assessments and NSAID intake were assessed at study entry, 6 weeks, 3, 6 and 12 months for the anti-TNF group and at study entry, 6 and 12 months for the control group. Outcome measurements were the percentage of patients using NSAID and the recently developed, and by ASAS recommended, ASAS-NSAID score. Results: At study entry, 80% of patients in the anti-TNF group used NSAID, which was just significantly lower than in the control group. This percentage decreased to 46% at 6 months and 43% at 12 months. The ASAS-NSAID score decreased significantly as well. All disease activity and function parameters improved significantly at all follow-up visits compared to study entry in the anti-TNF group. In the control group, the percentage of patients that used NSAID remained stable over time, namely 87% at study entry, 87% at 6 months and 84% at 12 months. In addition, the ASAS-NSAID score was not significantly different during the follow up. Conclusion: NSAID use differs in AS patients with and without anti- TNF drugs during the first year of follow-up. The percentage of patients using NSAID in the anti-TNF group decreased, as well as the ASAS-NSAID score. NSAID use and the ASAS-NSAID score remained relatively constant in the control group during the follow-up. This study confirms that ASAS-NSAID score can serve as objective measure in evaluation of the magnitude of NSAID intake in observational studies.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Faculty supervisor: and Brouwer, dr. E. rheumatologist/internist(UMCG) |
| Supervisor name: | External supervisor: and Kapelle, dr. J. internist and and Spoorenberg, dr. A. rheumatologist (MCL) and Daily supervisors: and Arends, dr. S. researcher and and Veer, dr. E. van der clinical biochemist (UMCG |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:53 |
| Last Modified: | 25 Jun 2020 10:53 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/1352 |
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