Halk, A.B. (Anne Berthe) (2012) Evaluating the role of Betapapillomavirus infection related to the risk of cutaneous squamous cell carcinoma in organ transplant recipients; a prospective pilot study. thesis, Medicine.
Full text available on request.Abstract
Introduction: Case-control studies have advocated a potential role of Betapapillomaviruses (Beta-PV) in the development of cutaneous squamous cell carcinoma (SCC). However, addi-tional prospective studies are needed to assess causal inference. The primary aim of this study was to clarify the role of Beta-PV infection in SCC development in organ transplant recipients (OTRs), as they have increased risk of developing skin cancer. Methods: For 101 OTRs we determined Beta-PV antibodies in serum and Beta-PV DNA presence in eyebrow hairs shortly after transplantation and at five subsequent time points during the next 18 months. We evaluated whether and which of these infection markers pre-dicted future SCC risk in this cohort using Cox proportional hazard analyses. We also analyzed the kinetics of these markers during the first 18 months after transplantation and evaluated if appearance of Beta-PV antibodies had potential value as predictive marker of increased SCC risk. Results: Between recruitment (2002-2004) and follow-up (2012) a total of seven patients developed SCC. A (not statistically significant) association between Beta-PV seropositivity and increased SCC risk was found, irrespective of simultaneous presence of concordant DNA. Presence of higher number of different Beta-PV DNA types was also associated with in-creased SCC risk. Serologic markers of Beta-PV infection remained quite stable over the first 18 months post transplantation, in contrast to Beta-PV DNA for which a significant increase in number of different types was seen. Seroconversion for Beta-PV within the first 18 months after transplantation was not significantly associated with SCC development. Discussion: presence of antibodies against at least one Beta-PV type as well as number of different Beta-PV DNA types in eyebrow hairs may have value in determining elevated SCC risk in OTRs. Larger prospective studies, with broader time scope, exploring both serologic and DNA infection parameters measured at multiple time points around transplantation until the de¬velopment of SCC are needed to clarify the role of Beta-PV in SCC development in OTRs further.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Facultair begeleider: and Vodegel, dr. R. Dermatoloog |
| Supervisor name: | Bouwes Bavinck dr. J.N., Dermatoloog |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:51 |
| Last Modified: | 25 Jun 2020 10:51 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/1173 |
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