The relation between CT-based measurements of skeletal muscle mass and post-operative complications after HIPEC treatment for peritonitis carcinomatosis

Luit, L.R. van (2017) The relation between CT-based measurements of skeletal muscle mass and post-operative complications after HIPEC treatment for peritonitis carcinomatosis. thesis, Medicine.

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Abstract

Introduction - Peritonitis carcinomatosis (PC) is a disease, characterized by metastasized tumors in the abdominal cavity, causing an inflammation reaction of the peritoneum. A relatively new treatment for this disease is Hyperthermic Intraperitoneal Chemotherapy (HIPEC), preceded by cytoreductive surgery (CRS). Research has shown a relation between depletion of skeletal muscle mass (sarcopenia) and the incidence of postoperative complications in patients treated for colon carcinoma. A similar relation, specific for patients after HIPEC treatment, is being investigated in this research. Methods - In this research, data of 104 patients is analyzed. The degree of skeletal muscle mass depletion was analyzed by CT measurements of the cross-sectional area of all skeletal muscle mass (SMI) or both psoas muscles (TPI) at the L3 vertebral body level. Results - 31 (29.9%) patients were classified as sarcopenic using the SMI, and 2 (1.9%) patients were classified as sarcopenic using the TPI. Hospitalization period (OR: 1.08; 95% CI: 1.02-1.15; p = 0.01) and number of organs removed (OR: 1.76; 95% CI: 1.26-2.47; p < 0.01) were independent statistical significant risk factors associated with the incidence of postoperative complications Conclusion - In this research, no relationship between sarcopenia and the development of postoperative complications could be demonstrated.

Item Type:	Thesis (Thesis)
Supervisor name:	Bock, prof. dr. GH de and Departments of Epidemiology and Leeuwen, dr. BL van and Radiology and Surgical Oncology and Weerink, drs. LBM
Faculty:	Medical Sciences
Date Deposited:	25 Jun 2020 10:51
Last Modified:	25 Jun 2020 10:51
URI:	https://umcg.studenttheses.ub.rug.nl/id/eprint/1164

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