Nagy, R.A. (Ruxandra) (2017) Predictive value of anti-oxidative function of follicular fluid high density lipoproteins for outcomes of modified natural cycle IVF. thesis, Medicine.
Full text available on request.Abstract
development takes place, and its composition is crucial for normal follicular growth. Cholesterol is an abundant element of FF and it is the substrate for steroid hormone production. The main form of transport of cholesterol in FF are high density lipoproteins (HDL). Studies on FF HDL have thus far mainly focused on their role as cholesterol carriers, and not so much on other biological functions. Therefore, the aim of the present research is to study the relationship of HDL function with oocyte and embryo parameters in modified natural cycle-IVF. Methods: Anti-oxidative function of HDL was measured in FF and matched serum from 375 modified natural cycle-IVF procedure that took place between August 2013 and April 2017. Anti-oxidative function was measured as the capacity of HDL to prevent native LDL oxidation in vitro. The association between HDL function and oocyte, embryo and pregnancy parameters was analyzed. Results: The anti-oxidative function of FF was significantly higher than that of matching serum (P < 0.001) and more than 80% of FF anti-oxidative function was attributable to FF HDL. In addition, higher levels of FF HDL anti-oxidative function were associated with lower percentage of embryo fragmentation and with the development of a top quality embryo, associations that persisted after adjustment for BMI and smoking (P = 0.012 and P = 0.011, respectively). However, FF HDL anti-oxidative function had no predictive value for the occurrence of pregnancy. Conclusion: The present study demonstrates that FF has anti-oxidative capacities that are mainly attributable to HDL. Moreover, increased FF anti-oxidant function predicts improved embryo quality, suggesting a potential role of local antioxidants in embryo development.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Supervisor: and Tietge, prof. dr. Uwe J.F. and Co-supervisors: dr. Aafke P.A. van Montfoort, prof. dr. Anne and Department of Pediatrics, Center for Liver and Metabolic Dis and Department of Obstetrics and Gynecology, Center for Reproduc and University Medical Center Groningen, Groningen |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:49 |
| Last Modified: | 25 Jun 2020 10:49 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/1005 |
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