Changing of Quality of Life in patients with laryngeal and hypopharyngeal carcinoma undergoing primary (chemo)radiation or primary surgery followed by postoperative (chemo)radiation

Nasrollah, M. (Mahtab) (2015) Changing of Quality of Life in patients with laryngeal and hypopharyngeal carcinoma undergoing primary (chemo)radiation or primary surgery followed by postoperative (chemo)radiation. thesis, Medicine.

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Abstract

Introduction: Organ preservation protocols are preferred as better QoL is assumed. This assumption is not yet thoroughly investigated. Objective: The primary aim is to compare QoL of patients with stage III and IV laryngeal- and hypopharyngeal cancer treated with (C)RT and those treated with TLE and postoperative (C)RT. Study design and study population: A retrospective observational cohort study performed on a prospectively built database containing stage III and IV laryngeal- and hypopharyngeal cancer treated with primary (C)RT and those treated with primary TLE and postop (C)RT. Main study parameters: The questionnaires, EORTC QLQ-H&N35 and QLQ-C30, which have been used for collecting quality of life data at the time points: baseline, 1, 2, 3, 4, 5, 6, 7 and 12 weeks, and 6, 12, 18 and 24 months. Results: 33 patients were excluded. No difference in global QoL score was found in the EORTC QLQ-C30 questionnaire. However, the EORTC QLQ-H&N35 questionnaire showed difference during the (C)RT treatment period, in the favor of the (C)RT only patients. Discussion/conclusion: there were some limitations, more investigations is needed.

Item Type:	Thesis (Thesis)
Supervisor name:	Supervisor: and Langendijk, Prof. dr. JA and Department of Radiation Oncology and University Medical Center Groningen
Faculty:	Medical Sciences
Date Deposited:	25 Jun 2020 11:00
Last Modified:	25 Jun 2020 11:00
URI:	https://umcg.studenttheses.ub.rug.nl/id/eprint/2032

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