Zwartjens, J. (Judith) (2019) Verminderde handknijpkracht en loopsnelheid bij ouderen is geassocieerd met het optreden van negatieve klinische uitkomsten. thesis, Medicine.
Full text available on request.Abstract
Introduction: Frailty is a term used to describe the overall condition of the elderly. The determination of degree of frailty can be time-consuming and is generally difficult. The physical frailty phenotype (PFP) is the most commonly used instrument for assessing frailty. It consists of 5 components; unintentional weight loss, reduced grip strength, poor endurance, reduced gait speed and low physical activity level. It is not known whether reduced grip strength and gait speed alone are related to adverse outcomes (hospitalization, falls, death). Different cut-off values for grip strength and gait speed are used in literature, such as the PFP and that of Dodds and Studenski, which we have investigated. Methods: This is a retrospective cohort study in patients of the geriatric outpatient clinic of Deventer Hospital. Grip strength and gait speed were measured as standard procedure. Cut-off values of the PFP and Dodds and Studenski were grip strength ≤ 18 kg and <16 kg for women, ≤ 30 kg and <27 kg for men and gait speed ≤ 0,76 m/s and <0,60 m/s, respectively. Follow-up lasted until 6 months after measurement, to record whether adverse outcomes had occurred. Results: Grip strength and/or gait speed was measured in 492 patients. After correction for confounders, only reduced grip strength and the combination of reduced grip strength and gait speed according to the PFP was associated with adverse outcomes (OR 3,807 (95% BI: 1,757- 8,248) and 2,073 (95% BI: 1,092-3,933)). Conclusion: Reduced grip strength and the combination of reduced grip strength and gait speed based on the PFP are independently associated with adverse outcomes. The combination seems best to assess the risk of adverse outcomes. For risk assessment of adverse outcomes, the cut-off values of the PFP are most accurate.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Facultair begeleider: and Zeeman, M. and Locatie - Deventer Ziekenhuis and Afdeling - Geriatrie |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:48 |
| Last Modified: | 25 Jun 2020 10:48 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/934 |
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