Cerebral oxygen saturation during and after apnea of prematurity.

Dotinga, B.M. (2015) Cerebral oxygen saturation during and after apnea of prematurity. thesis, Medicine.

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Abstract

Background Apneic episodes are common in preterm born infants and are generally treated by administering additional FiO2, which is associated with a peripheral arterial and cerebral oxygen saturation overshoot during recovery. Oxidative stress may have detrimental effects on the developing brain. Objectives To identify the underlying mechanism causing an increase in cerebral saturation during recovery from apnea of prematurity. Methods Data concerning peripheral arterial saturation (SpO2), NIRS-monitored cerebral tissue oxygen saturation (rcSO2), transcutaneous carbon dioxide tension (tcCO2) and heart rate were prospectively collected in the first weeks of life. Cerebral fractional tissue oxygen extraction (cFTOE) and Δ tcCO2 were calculated. Results We included three apneas in ten spontaneously breathing premature infants (gestational age 28.3 ± 2.1 weeks; mean ± SD). At group level, SpO2 and rcSO2 values during recovery from apnea were not significantly different from baseline values. In the presence of cerebral oxygen saturation overshoot after apnea, minimum SpO2 values during apnea were significantly lower (p < 0.05). Using multivariable modeling, only the combination of minimum SpO2 during apnea and the administration of additional FiO2 seemed to predict of the incidence of cerebral oxygen saturation overshoot (p < 0.05). Conclusion Cerebral oxygen saturation overshoot during recovery from apneic episodes may be caused by desaturation and oxygen administration. Further research is needed to confirm these results.

Item Type:	Thesis (Thesis)
Supervisor name:	Kooi, E.M.W. MD PhD
Faculty:	Medical Sciences
Date Deposited:	25 Jun 2020 10:48
Last Modified:	25 Jun 2020 10:48
URI:	https://umcg.studenttheses.ub.rug.nl/id/eprint/925

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