Menapal, L. (Laila) (2018) Development of surgical techniques for ex-vivo perfusion of end stage diseased explanted lungs. thesis, Medicine.
Full text available on request.Abstract
Introduction End stage lung disease (ESLD) is one of the leading causes of death worldwide. The patients with ESLD have a very poor quality of life. Lung transplantation is the only treatment option available for the patients with ESLD. However, the donors for lung transplantation are outnumbered by the patients on the waiting list, which leads to a lot of patients dying while on the waiting list to receive lung transplantation. Ex-vivo lung perfusion has helped in increasing the donor lung pool but there is still a high percentage of patients waiting to receive lung transplantation. It is therefore essential to provide these patients with an alternative therapeutic option. Aim The aim of our study is to develop different surgical techniques to be able to keep the diseased explanted lungs alive later on and eventually cure these lungs. Methods We included 13 lung-sets in our study (8 porcine lungs and 7 explanted human lungs) of which one lung set from both human and porcine lungs was excluded due to the excessive damage. Various surgical techniques were tested out to cannulate the pulmonary vasculature and intubate the bronchi. The excessive amount of damage in the explanted human lungs made it extremely hard to develop appropriate methods to perfusate these lungs.The porcine lungs were collected from the butcher’s shop while the human lungs were provided directly to us after they were removed from the patient. All experiments were performed at the surgical lab in UMCG. Results Of the various surgical methods, the French cannulas and silicone tubes turned out to be ideal to cannulate damaged pulmonary arteries without causing any further damage. For bronchial intubation both endotracheal tube and XVIVO cannula can be used. To prevent air and fluid leakage at the site of stitches, super glue should be applied. Conclusion The various surgical methods developed can be used to perfusate the explanted lungs ex-vivo thereby providing a platform to treat these lungs later on.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Faculty supervisor: and Verschuuren, dr. E.A.M. and Department of Pulmonary diseases; Department of CardioThorac |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:48 |
| Last Modified: | 25 Jun 2020 10:48 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/920 |
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