Alsada, Z. (Zainab) (2019) Plasma PD-L1 is a suitable Diagnostic and Treatment Response Marker in Classical Hodgkin’s Lymphoma. thesis, Medicine.
Full text available on request.Abstract
Hodgkin lymphoma (HL) is a cancer of the lymphatic system that mostly affects B-cells. Improvements in HL treatments have increased the cure rate to 80%. However, between 10-30% of HL patients relapse after achieving a complete response and 5-10% are refractory to initial therapy. It is a matter of research to identify those group of patients for better optimization of the treatment plan, especially with the emergence of new promising treatment agents such as Nivolumab. Nivolumab modulates the immune response by blocking the PD-1 pathway checkpoint. In this study, the significance of PD-1 pathway regulatory molecules was examined; PD-1, PD-L1, PD-L2, CD83, VEGF and IDO as diagnostic, treatment monitoring and relapse predictor markers. ELISA was performed using the plasma of 72 newly diagnosed HL patients before and after therapy and the results were then compared to the plasma of healthy controls. Among the six studied markers, only PD-L1, CD83 and VEGF plasma levels were higher in HL patients compared to the controls. PD-L1 and VEGF level decreased significantly after therapy. PD-L1 levels were significantly higher in patients with advanced stage HL (IIb-IV) compared to patients with early stage HL (I-IIa) and it had a moderate correlation with the metabolic volume of the tumor. None of the six markers significantly correlated with bulky disease. This research shows that PD-L1 yielded the most promising results regarding its potential use as a diagnostic, treatment monitoring and relapse predictor marker in HL. Further studies are needed to examine the role of plasma PD-L1 as response predictor to PD-1 pathway inhibitors.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Faculty supervisor: and Visser, Lydia and Pathology and Medical Biology UMCG |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:48 |
| Last Modified: | 25 Jun 2020 10:48 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/907 |
Actions (login required)
 |
View Item |