Pietersma, Nienke Suzanne (2012) UPPER VERSUS LOWER LIP CANCER: ARE THERE REALLY DIFFERENCES? thesis, Medicine.
Full text available on request.Abstract
Introduction: Lip cancer is a rare malignancy of the head and neck region in the Netherlands. Generally, the impression exists that upper lip (UL) cancer has a worse prognosis than lower lip (LL) cancer. However, this is based on few studies and conflicting results have been reported. Objectives: The main objective was to investigate the difference in survival between UL and LL cancer. Additionally, we investigated which factors are associated with a risk of dying. Materials and methods: Data for 1989-2009 were derived from the Netherlands Cancer Registry of the North-Eastern region. Only primary squamous cell carcinoma (SCC) of the vermilion of the lip were included. Information on patient characteristics, tumour characteristics and treatment was collected. The crude 5-year overall survival (OS) rates and Hazard Ratios (HR) were calculated. Results: In this study 1126 SCCs of the vermilion border of the lip, observed in 1105 patients, were included. Most tumours were found in men (71.9%). Almost 90% presented on the lower lip (predominantly in men) and 10% on the upper lip (predominantly in women). Between the upper and lower lip SCCs, there were no significant differences in age distribution, tumour grade, tumour stage or involved surgical margins. The 5-year OS rate was the same for both tumour sites: 74%. In sex-stratified analysis, also no statistically significant differences in survival between UL and LL SCCs were found. Prognostic factors associated with a worse outcome were: male sex (HR 1.46; 95%CI 1.17 – 1.83), increasing age (per 10 years, HR 2.07; 95%CI 1.88 – 2.27), and high tumour stage (HR 2.60; 95%CI 1.56 – 4.33). Conclusions: Our results suggest that there is no difference in survival between upper and lower lip SCC.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Facultair begeleider: and Bock Prof. Dr. GH de ; Oncologische Epidemiologie, UMCG and RoodenburgProf. Dr. JLN, Hoofd-Hals oncologie and Visscher Dr. JGAM de, Hoofd-Hals oncologie |
| Supervisor name: | Integraal Kankercentrum Nederland (IKNL), Groningen and Directe begeleider: and Dijk Dr. BAC van ; Epidemiologie, IKNL |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:48 |
| Last Modified: | 25 Jun 2020 10:48 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/906 |
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