Influence of deep brain stimulation of the subthalamic nucleus on cognitivesymptoms in a rat model of Parkinson’s Disease

Holslag, J.A.H. (2016) Influence of deep brain stimulation of the subthalamic nucleus on cognitivesymptoms in a rat model of Parkinson’s Disease. thesis, Medicine.

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Abstract

Morbus Parkinson is a common neurodegenerative disease. It is best known for its cardinal motor symptoms caused by loss of dopamine, which can be alleviated by dopaminergic medication and deep brain stimulation (DBS) of the subthalamic nucleus (STN). But most patients also have non-motor symptoms. Attention deficit and impulsivity are among the commonest. There are indications that STN DBS affects these cognitive symptoms. Nevertheless, there is a lack of properly controlled studies, not confounded by varying influences. Therefor a study was performed to test attention and impulsivity in a rat model of parkinson’s, as well as the effect of STN DBS, thereof. A 3-class auditory oddball paradigm was used to test rats’ ability to quickly, and specifically react to a correct tone, but to ignore a standard and distractor tone. Our results show reduced attention and impulsivity in the 6-OHDA lesioned rat Parkinson’s model, but that STN DBS has no effect on these symptoms. Reduced attention has been shown in Parkinson before, while the impact of this disorder on impulsivity is less clear. This paradigm may therefore be useful to characterize the pathophysiological mechanisms leading to disturbed attention in Parkinson in more detail.

Item Type:	Thesis (Thesis)
Supervisor name:	Faculty supervisors: and Koning, M.A.J. de M.D. PhD. and Dijk, M.J.C. van M.D. PhD. and University Medical Centre Groningen
Supervisor name:	Second supervisors: and Krauss, J. K. M.D. and Schwabe, K. PhD. and Medizinische Hochschule Hannover
Faculty:	Medical Sciences
Date Deposited:	25 Jun 2020 10:39
Last Modified:	25 Jun 2020 10:39
URI:	https://umcg.studenttheses.ub.rug.nl/id/eprint/82

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