Water deprivation in ADPKD patients versus IgA nephropathy patients.

Duit, A.A.M. (2015) Water deprivation in ADPKD patients versus IgA nephropathy patients. thesis, Medicine.

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Abstract

Background and objectives: Autosomal dominant polycystic kidney disease (ADPKD) is a hereditary renal disease, characterized by the formation of numerous cysts in both kidneys. ADPKD patients are known to have an impaired concentrating capacity, however the mechanism behind this is unknown. Vasopressin is thought to have a deleterious role in the pathogenesis. In this study we investigate the role of vasopressin during water deprivation. Design, setting, participants, & measurements: 15 ADPKD patients and 15 IgA nephropathy patients with an impaired renal function (eGFR < 60 ml/min/1.73m2), sex and age matched, were included. They underwent a standard prolonged water deprivation test and both plasma and urine osmolality were measured, as well as plasma copeptin. During the test a synthetic form of AVP (dDAVP) was injected. Results: ADPKD patients tended to have a significantly lower urinary concentrating capacity two hours after administration of dDAVP (P=0.09). No significance was found between ADPKD patients and IgA nephropathy patients with regard to urine osmolality after water deprivation (P=0.17). Copeptin values did not differ significantly during the test (P=0.94 and P=0.80). Conclusions: ADPKD patients tend to have a worse concentrating capacity, compared to IgA nephropathy patients. The plasma vasopressin does not differ between these two groups. The urinary concentrating capacity is impaired in both diseases.

Item Type:	Thesis (Thesis)
Supervisor name:	Gansevoort, R.T. MD and Casteleijn, N.F. MD and Zittema, D. BSc
Faculty:	Medical Sciences
Date Deposited:	25 Jun 2020 10:47
Last Modified:	25 Jun 2020 10:47
URI:	https://umcg.studenttheses.ub.rug.nl/id/eprint/798

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