Fokkens (2012) Rol van geavanceerde glycatie eindproducten (AGEs) bij ablatio retinae. thesis, Medicine.
Full text available on request.Abstract
Objectives: Recently, it was suggested that advanced glycation endproducts (AGEs) could be involved in vitreo-retinal interface disease. The validated marker of AGE accumulation in long-lived tissues (skin autofluorescence (SAF)) may be a predictor in retinal detachment. We tested the hypothesis that skin autofluorescence values correlate with pentosidine values of the vitreous body. Methods: In 33 patients (19 male, aged 19 – 89 years) pentosidine values were analysed using high performance liquid chromatography and SAF values were determined using AGE reader measurements. Severity of retinal detachment was established during vitrectomy for retinal detachment in all patients. Using regression analysis, the effect of different variables on pentosidine values, SAF values and severity of detachment was measured. Results: Pentosidine concentration varied between 2.94*10-4 and 6.8*10-2 mol/mol collagen (median 4.3*10-3). Skin autofluorescence values varied between 1.23 en 2.78 AU (mean 2.00). There was no significant correlation between vitreous pentosidine- and SAF values. Patients with proliferative vitreoretinopathy (PVR) showed significantly higher pentosidine values in their vitreous than patients without PVR (p < 0.01) and showed significantly higher SAF values (p < 0.001). Logistic regression analysis of PVR provided a model with autofluorescence values (p =.020) and pentosidine values as variables (p = .053), the latter almost significant. Conclusion: Our results showed no relation between vitreous pentosidine values and skin autofluorescence, but they suggest a role of AGEs in proliferative vitreoretinopathy. SAF values seem to display this role and predict the risk of PVR. Therefore, AGE reader measurements may be a tool in the choice of retinal detachment treatment with regard to the risk of PVR.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Begeleiding: and Smit, Dr. Andries afdeling interne geneeskunde and Dr. Leonie Los afdeling oogheelkunde and Lokatie: Rijksuniversiteit Groningen (RUG) / Universitair Me |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:46 |
| Last Modified: | 25 Jun 2020 10:46 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/793 |
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