Christoffers, W.A. (2012) Contact allergy for isobornyl acrylate : Contact allergy for isobornyl acrylate. thesis, Medicine.
Full text available on request.Abstract
BACKGROUND: Allergic contact dermatitis to isobornyl acrylate has been described in only two cases in literature. Because of this rareness, many institutes do not investigate isobornyl acrylate in their (meth) acrylates patch test series. In our Dermatology department an industrial worker presented with a therapy resistant hand eczema and contact allergies for various non-relevant acrylates. After scrupulous examination of his work area and an expanded patch test, the culprit allergen turned out to be isobornyl acrylate. OBJECTIVE: Exploring whether it was relevant to add isobornyl acrylate to the (meth) acrylate test series in the UMCG and to investigate the optimal patch test concentration for isobornyl acrylate. Secondary objective was to establish cross reactivity with other acrylates. METHODS: Explorative observational study: former patients with a proven acrylate sensitization, diagnosed between 1-1-2000 and 1-1-2012 were selected from the patch test database of the UMCG. Included subjects were patch tested with a dilution series of isobornyl acrylate (0.3%, 0.1%, 0.033% and 0.01%) and the previous tested (meth) acrylates series. Readings were performed on D2, D3 and D7 and graded according the guidelines of the ICDRG. RESULTS: Twelve subjects were patch tested with the isobornyl acrylate dilution series. None of them showed signs of sensitization; however 3 subjects (25%) developed an irritant reaction to 0.3% dilution on D3. CONCLUSION: Isobornyl acrylate allergy seems to be rare and this study provides insufficient support for isobornyl acrylate to be added to the (meth) acrylate series. Cross-reactivity with other acrylates could not be demonstrated. The ideal patch test concentration of isobornyl acrylate seems to be 0.1%.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Supervisor: and Schuttelaar, Dr. M.L.A. Dermatologist & Chef de Clinique and Institution: Department of Dermatology, University Medical |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:46 |
| Last Modified: | 25 Jun 2020 10:46 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/788 |
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