Stenvers, E. (Elke) (2015) Risicofactoren voor een hartinfarct in de LifeLines populatie. thesis, Medicine.
![[img]](https://umcg.studenttheses.ub.rug.nl/style/images/fileicons/text.png) |
Text
StenversE.pdf Restricted to Registered users only Download (972kB) |
Abstract
Introduction Cardiovascular disease is one of the most important causes of death in the Netherlands. It is a major limitation in everyday life and it contributes largely to the rising cost of healthcare. Myocardial infarctions, stroke or death from vascular disease may occur suddenly. People get often only in touch with medical care when symptoms and diseases already incurred. By identifying risk factors as potential new targets for primary prevention, the morbidity and mortality of cardiovascular disease can be reduced. In the LifeLines study we investigated risk factors associated with myocardial infarction. Methods This cross sectional cohort study is using the LifeLines population(n=95013). A myocardial infarction is defined with the aid of an algorithm which is formed from questionnaires and measurements of LifeLines. The relationship of many risk factors with a myocardial infarction have been examined on the basis of logistic regression analyses. Results The mean age (± standard deviation(SD)) of the patients was 61 ± 15 years. The percentage of men in the control group (41%) was significantly lower than in the myocardial infarction group (79%). We studied the already known risk factors of the INTERHEART study in the LifeLines population and their relationship with a myocardial infarction. In addition, we studied unknown risk factors for a myocardial infarction. The risk factors diabetic, smoking, hypertension, alcohol, activity, abdominal obesity, ApoB/ApoA1 ratio, fruit and vegetable intake and psychosocial index (from the INTERHEART study) declared 20% for myocardial infarction of the northern Dutch population. The final model contains the risk factors atherosclerosis, age, cholesterol, gender, arrhythmia, heart rate, triglycerides, monocytes, BMI, FEV1, smoking, hemoglobin, heart valve problems, butter intake, phosphate, muesli intake, systolic blood pressure, rating their own health, tea intake, number of person per household, ready meal intake and wheezing, which explain 32%. Conclusion The nine variables from the INTERHEART study in the northern Dutch population do have a 20% relationship with myocardial infarction. When adding other possible risk factors, the model relates 32% with myocardial infarctions in the LifeLines population. These findings are worthwhile to do more research on these variables and ask for primary prevention in the future.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Harst, Prof. Dr. P. van der and Hartman, Mw. Drs. H.T. |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:46 |
| Last Modified: | 25 Jun 2020 10:46 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/778 |
Actions (login required)
 |
View Item |